What is the Ofloxacin?

Ofloxacin is Off-white solid, while it's Molecular Formula is C18H20FN3O4. Off-white solid Ofloxacin is a fluorinated quinolone antibacterial.This compound is a contaminant of emerging concern (CECs).

What is the CAS number for Ofloxacin?

The CAS number of Ofloxacin is 82419-36-1.

What is Ofloxacin (82419-36-1) used for?

Ofloxacin is a broad-spectrum fluoroquinolone antibiotic that prevents supercoiling of bacterial chromosomes by DNA gyrase. It is active against Gram-positive and Gram-negative bacteria with MIC90s ranging from 0.39 to 3.13 μg/ml for clinical isolates of S. aureus, S. epidermidis, S. pyogenes, and S. faecalis and ≤0.78 μg/ml for N. gonorrhoeae and various species of Enterobacteriaceae. Ofloxacin is active in vivo, with ED50 values ranging from 0.7 to 75.1 mg/kg in infected mice. Formulations containing ofloxacin have been used to treat urinary tract infections, gonorrhea, prostatitis, and gastroenteritis.InChI:InChI=1/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1

What is the Ofloxacin?

Ofloxacin is Off-white solid, while it's Molecular Formula is C18H20FN3O4. Off-white solid Ofloxacin is a fluorinated quinolone antibacterial.This compound is a contaminant of emerging concern (CECs).

What is the CAS number for Ofloxacin?

The CAS number of Ofloxacin is 82419-36-1.

What is Ofloxacin (82419-36-1) used for?

Ofloxacin is a broad-spectrum fluoroquinolone antibiotic that prevents supercoiling of bacterial chromosomes by DNA gyrase. It is active against Gram-positive and Gram-negative bacteria with MIC90s ranging from 0.39 to 3.13 μg/ml for clinical isolates of S. aureus, S. epidermidis, S. pyogenes, and S. faecalis and ≤0.78 μg/ml for N. gonorrhoeae and various species of Enterobacteriaceae. Ofloxacin is active in vivo, with ED50 values ranging from 0.7 to 75.1 mg/kg in infected mice. Formulations containing ofloxacin have been used to treat urinary tract infections, gonorrhea, prostatitis, and gastroenteritis.InChI:InChI=1/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1

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Fluorinated compounds

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82419-36-1

Product Name：Ofloxacin
Molecular Formula：C₁₈H₂₀FN₃O₄
Purity：99%
Molecular Weight：361.373

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Product Details;

CasNo： 82419-36-1

Molecular Formula： C₁₈H₂₀FN₃O₄

Appearance： Off-white solid

Wholesale Factory Supply Ofloxacin 82419-36-1 Cheapest Price

Molecular Formula:C18H20FN3O4
Molecular Weight:361.373
Appearance/Colour:Off-white solid
Vapor Pressure:6.7E-14mmHg at 25°C
Melting Point:270-275 °C
Refractive Index:1.669
Boiling Point:571.5 °C at 760 mmHg
PKA:5.19±0.40(Predicted)
Flash Point:299.4 °C
PSA：75.01000
Density:1.48 g/cm³
LogP:1.54690

Ofloxacin (Cas 82419-36-1) Usage

Description	Ofloxacin is an antibacterial agent that belongs to the fluoroquinolone class of antibiotics. It exhibits a broad spectrum of activity against both gram-positive and gram-negative bacteria.
Chemical Properties	Off-White Solid
Uses	Ofloxacin has been approved for the treatment of various infections, including those of the lower respiratory tract, such as chronic bronchitis and pneumonia caused by gram-negative bacilli. It is also used for the treatment of pelvic inflammatory disease and is effective against gonococcal and chlamydial infections. Ofloxacin is used to treat urinary tract infections, including prostatitis, skin and soft tissue infections, and infections caused by Staphylococcus, Streptococcus, and Gram-negative bacilli.
Definition	ChEBI: An oxazinoquinolone carrying carboxy, fluoro, methyl and 4-methylpiperazino substituents. A synthetic fluoroquinolone antibacterial agent, it inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Spectrum of Activity	Ofloxacin is effective against a wide range of microorganisms. It has demonstrated good activity against enterobacteria, including strains resistant to nalidixic acid. It is also active against other bacteria such as Aeromonas, Campylobacter, Vibrio, and Moraxella spp. Ofloxacin shows good activity against methicillin-sensitive Staphylococcus aureus (Staph. aureus), but it is less effective against streptococci, including Streptococcus pneumoniae, and enterococci.

InChI:InChI=1/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1

82419-36-1 Relevant articles

Nano-Fe3 O4@ZrO2-SO3 H as highly efficient recyclable catalyst for the green synthesis of fluoroquinolones

Nakhaei, Ahmad,Ramezani, Shirin,Shams-Najafi, Sayyed Jalal,Farsinejad, Sadaf

, p. 739 - 746 (2018/09/26)

Nano-Fe3 O4 @ZrO2-SO3 H (n-FZSA), was ut...

Ofloxacin A Review of its Antibacterial Activity, Pharmacokinetic Properties and Therapeutic Use

Jon P. Monk & Deborah M. Campoli-Richards

, Drugs volume 33, pages346–391 (1987)

After oral administration of a single 300mg dose of ofloxacin a peak serum concentration of about 3 mg/L is reached within 2 hours. Multiple dose administration for up to 14 days in healthy subjects did not produce accumulation at a dosage of 300mg twice daily, with peak concentrations ranging from 3 to 6 mg/L on the final day.

82419-36-1 Process route

: 109-01-3
1-methyl-piperazine

: 82419-35-0
9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]-benzoxazine-6-carboxylic acid

: 82419-36-1,83380-47-6
ofloxacin

Conditions

Conditions	Yield
With potassium hydroxide; In water; at 60 ℃; for 6h; Time; Solvent;	95.8%
With nano iron oxide on ZrO₂ coated sulfonic acid; In water; for 0.416667h; Reflux;	89%
at 150 ℃; Microwave irradiation;	83%
In dimethyl sulfoxide; at 100 - 140 ℃; for 12h;	62%

In dimethyl sulfoxide; at 100 ℃; for 2h;
In water; dimethyl sulfoxide;
With triethylamine; In dimethyl sulfoxide; at 90 ℃;

: 109-01-3
1-methyl-piperazine

: 82419-34-9
ethyl 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate

: 82419-36-1,83380-47-6
ofloxacin

Conditions

Conditions	Yield
With acetic acid; In water; N,N-dimethyl-formamide; at 70 - 105 ℃; for 10h; Temperature; Reagent/catalyst; Solvent;	87.9%

82419-36-1 Upstream products

109-01-3
1-methyl-piperazine
82419-35-0
9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]-benzoxazine-6-carboxylic acid
139535-20-9
8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid acetoxymethyl ester
139535-21-0
8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 1-acetoxy-ethyl ester

82419-36-1 Downstream products

151377-74-1
9-fluoro-2,3-dihydro-3-methyl-10-(N-methyl-N',N-diformyl-2-aminoethylamino)-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
100986-85-4
levofloxacin
100986-86-5
(R)-ofloxacin
117678-37-2
4-[6-carboxy-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazin-10-yl]-1-methylpiperazine 1-oxide