125971-94-0
- Product Name：Atorvastatin intermediatesAts-8
- Molecular Formula：C14H23NO4
- Purity：99%
- Molecular Weight：269.341
Product Details;
CasNo： 125971-94-0
Molecular Formula： C14H23NO4
Appearance： white to light yellow crystal powder
Sale Quality Factory Supply Atorvastatin intermediatesAts-8 125971-94-0 Efficient Transportation
- Molecular Formula:C14H23NO4
- Molecular Weight:269.341
- Appearance/Colour:white to light yellow crystal powder
- Vapor Pressure:1.73E-05mmHg at 25°C
- Melting Point:65-69 °C
- Refractive Index:1.439
- Boiling Point:364.1 °C at 760 mmHg
- Flash Point:159.2 °C
- PSA：68.55000
- Density:1.016 g/cm3
- LogP:2.54208
(4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate(Cas 125971-94-0) Usage
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Chemical Properties |
white to light yellow crystal powde |
|
Uses |
Atorvastatin Intermediate |
InChI:InChI=1/C14H23NO4/c1-13(2,3)19-12(16)9-11-8-10(6-7-15)17-14(4,5)18-11/h10-11H,6,8-9H2,1-5H3/t10-,11-/m1/s1
125971-94-0 Relevant articles
Atorvastatin calcium intermediate as well as preparation method and application thereof
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Paragraph 0089; 0090; 0092; 0093-0094; 0096; 0097-0098; 0100, (2019/04/04)
The invention discloses an atorvastatin ...
Preparation method of atorvastatin calcium intermediate
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Paragraph 0044-0049; 0050-0055; 0056-0061; 0062-0067, (2018/03/24)
The invention belongs to the technical f...
Preparation method of atorvastatin calcium intermediate
-
, (2018/10/11)
The invention belongs to the field of me...
Atorvastatin calcium side chain intermediate preparation method
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Paragraph 0027-0031, (2016/10/08)
The present invention provides an atorva...
125971-94-0 Process route
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- 848644-99-5
(5R)-1,1-dimethylethyl 6-cyano-5-hydroxy-3-oxo-hexanoate
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- 7397-46-8
diethyl methoxy borane
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- 125971-93-9
(3R,5R)-tert-butyl-6-cyano-3,5-dihydroxyhexanoate
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- 125971-94-0,196085-84-4
2-((4R, 6R)-6-cyanomethyl-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid tert-butyl ester
| Conditions | Yield |
|---|---|
|
With sodium borohydrid; acetic acid; In tetrahydrofuran; methanol; water; ethyl acetate;
|
-
- 125971-93-9
(3R,5R)-tert-butyl-6-cyano-3,5-dihydroxyhexanoate
-
- 77-76-9
2,2-dimethoxy-propane
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- 125971-94-0,196085-84-4
2-((4R, 6R)-6-cyanomethyl-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid tert-butyl ester
| Conditions | Yield |
|---|---|
|
With toluene-4-sulfonic acid; In acetone; at 20 ℃; for 5h;
|
88.3% |
|
With pyridinium p-toluenesulfonate; In acetone; at 20 ℃; for 5h;
|
85% |
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With methanesulfonic acid; In toluene; at 20 ℃; for 8h;
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85.3% |
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With methanesulfonic acid; Yield given;
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|
|
(3R,5R)-tert-butyl-6-cyano-3,5-dihydroxyhexanoate; 2,2-dimethoxy-propane; With methanesulfonic acid; In acetone; at 29 - 30 ℃; for 3 - 4h;
With sodium hydrogencarbonate; In water; acetone; pH=7;
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|
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With methanesulfonic acid; In acetone; at 29 - 30 ℃; for 3 - 4h;
|
|
|
methanesulfonic acid; In acetone; at 29 - 30 ℃; for 3 - 4h;
|
|
|
With acid resin catalyst; at 25 ℃; for 6h; Temperature;
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31.34 g |
125971-94-0 Upstream products
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143-33-9
sodium cyanide
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141942-87-2
[(4R,6S)-6-(4-Chloro-benzenesulfonyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-acetic acid tert-butyl ester
-
141942-88-3
[(4R,6S)-6-(4-Bromo-benzenesulfonyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-acetic acid tert-butyl ester
-
141942-89-4
tert-butyl 2-[(4R,6S)-2,2-dimethyl-6-[(4-nitrophenylsulfonyloxy)methyl]-1,3-dioxan-4-yl]acetate
125971-94-0 Downstream products
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125971-86-0
tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
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134523-01-6
atorvastatin sodium
-
134395-00-9
(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester
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125971-95-1
tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate
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