289042-12-2
- Product Name：Rosuvastatin intermediate R-1
- Molecular Formula：C29H40FN3O6S
- Purity：99%
- Molecular Weight：577.718
Product Details;
CasNo： 289042-12-2
Molecular Formula： C29H40FN3O6S
Appearance： White or off-white powder
Reliable Quality Factory Supply High Purity Rosuvastatin intermediate R-1 289042-12-2 Safe Delivery
- Molecular Formula:C29H40FN3O6S
- Molecular Weight:577.718
- Appearance/Colour:White or off-white powder
- Vapor Pressure:0mmHg at 25°C
- Melting Point:153-155°C
- Refractive Index:1.545
- Boiling Point:673.348 °C at 760 mmHg
- PKA:-0.43±0.10(Predicted)
- Flash Point:361.028 °C
- PSA：116.30000
- Density:1.211 g/cm3
- LogP:6.53790
289042-12-2 Relevant articles
Preparation method of rosuvastatin calcium
-
Paragraph 0028-0031, (2020/06/17)
The invention belongs to the technical f...
Rosuvastatin calcium intermediate compound
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Paragraph 0137-0141; 0145-0146, (2020/10/14)
The invention belongs to the field of or...
Rosuvastatin calcium impurity and method for controlling quality of rosuvastatin calcium
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Paragraph 0067-0068; 0076-0077, (2019/06/30)
The invention provides a rosuvastatin ca...
Preparation method of statins intermediate
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Paragraph 0052-0055; 0062-0065; 0072-0075; 0082-0085, (2018/11/27)
The invention discloses a preparation me...
289042-12-2 Process route
-
![[4-[4-fluorophenyl-6-(1-methylethyl)-2-[N-methyl-(N-methanesulfonyl)amino]]-5-pyrimidinyl]methylphenyltriphenylphosphonium bromide](/upload/2023/8/de9afbec-114c-412d-a891-7f44131bbe7b.png)
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[4-[4-fluorophenyl-6-(1-methylethyl)-2-[N-methyl-(N-methanesulfonyl)amino]]-5-pyrimidinyl]methylphenyltriphenylphosphonium bromide
-
![tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate](/upload/2023/8/ab78703d-70d1-49ca-ba5c-7d6f3a6184c3.png)
- 124752-23-4
tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
-
![2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester](/upload/2023/8/810f5bd1-bdb7-404f-930d-23e0a50e2ae9.png)
- 289042-12-2,1378943-63-5
2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester
| Conditions | Yield |
|---|---|
|
With potassium carbonate; In dimethyl sulfoxide; at 20 - 70 ℃; Concentration; Temperature; Inert atmosphere;
|
89% |
|
With potassium carbonate; In dimethyl sulfoxide; at 25 - 75 ℃; for 2h;
|
85% |
|
With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 2.16h;
|
80% |
|
With potassium carbonate; In toluene; at 95 ℃; for 6h; Temperature;
|
76% |
|
With potassium carbonate; In dimethyl sulfoxide; at 25 - 75 ℃; for 2h;
|
75% |
|
With potassium carbonate; In dimethyl sulfoxide; at 70 - 75 ℃; for 2h;
|
75% |
-
![tributyl[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-ylmethyl]phosphonium bromide](/upload/2023/8/15bde0ed-bc04-4277-8537-092d10c2d254.png)
- 853066-73-6
tributyl[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-ylmethyl]phosphonium bromide
-
- 124752-23-4
tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
-
- 289042-12-2,1378943-63-5
2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester
| Conditions | Yield |
|---|---|
|
With potassium carbonate; In dimethyl sulfoxide; at 25 - 75 ℃; for 5 - 7h;
|
88% |
|
With potassium carbonate; In dimethyl sulfoxide; at 25 - 75 ℃; Temperature;
|
83.21% |
289042-12-2 Upstream products
-
124752-23-4
tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
-
956034-92-7
N-{4-(4-fluorophenyl)-6-isopropyl-5-[(1-methyl-1H-benzo[d]imidazol-2-ylsulfonyl)methyl]pyrimidin-2-yl}-N-methylmethanesulfonamide
-
853066-73-6
tributyl[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-ylmethyl]phosphonium bromide
-
894787-92-9
N-(5-bromo-4-(4-fluorophenyl)-6-isopropylpyriinidin-2-yl)-N-methylmethanesulfonamide
289042-12-2 Downstream products
-
355806-00-7
rosuvastatin tert-butyl ester
-
355805-96-8
rosuvastatin methylamine salt
-
894787-93-0
{(4R,6S)-6-[(E)-2-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid
-
1207460-30-7
[(4R,6S)-6-{(E)-2-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]ethenyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate 1,1-dimethylethylammonium
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