What is the 2,4-Dichloro-5-fluoropyrimidine?

2,4-Dichloro-5-fluoropyrimidine is yellow to orange crystalline solid, while it's Molecular Formula is C4HCl2FN2. yellow to orange crystalline solid 2,4-Dichloro-5-fluoropyrimidine can be used as a starting material to synthesize: 5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides as potential kinase inhibitors. A series of 2,4-diamino-5-fluoropyrimidine derivatives as potential protein kinase Cθ inhibitors. 2,4-Bisanilinopyrimidine derivatives as potential aurora kinases inhibitors. 5-fluoro-N,N-bis(4-methoxyphenyl)-2,4-pyrimidinediamine by reacting with p-methoxy aniline in the presence of DIPEA. 2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine by Suzuki coupling reaction in the presence of (4-fluorophenyl)boronic acid triphenylphosphine, and palladium(II) acetate catalyst. 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a scaffold, which is used in the preparation of potent deoxycytidine kinase inhibitors.

What is the CAS number for 2,4-Dichloro-5-fluoropyrimidine?

The CAS number of 2,4-Dichloro-5-fluoropyrimidine is 2927-71-1.

What is 2,4-Dichloro-5-fluoropyrimidine (2927-71-1) used for?

InChI:InChI=1/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H

What is the 2,4-Dichloro-5-fluoropyrimidine?

2,4-Dichloro-5-fluoropyrimidine is yellow to orange crystalline solid, while it's Molecular Formula is C4HCl2FN2. yellow to orange crystalline solid 2,4-Dichloro-5-fluoropyrimidine can be used as a starting material to synthesize: 5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides as potential kinase inhibitors. A series of 2,4-diamino-5-fluoropyrimidine derivatives as potential protein kinase Cθ inhibitors. 2,4-Bisanilinopyrimidine derivatives as potential aurora kinases inhibitors. 5-fluoro-N,N-bis(4-methoxyphenyl)-2,4-pyrimidinediamine by reacting with p-methoxy aniline in the presence of DIPEA. 2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine by Suzuki coupling reaction in the presence of (4-fluorophenyl)boronic acid triphenylphosphine, and palladium(II) acetate catalyst. 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a scaffold, which is used in the preparation of potent deoxycytidine kinase inhibitors.

What is the CAS number for 2,4-Dichloro-5-fluoropyrimidine?

The CAS number of 2,4-Dichloro-5-fluoropyrimidine is 2927-71-1.

What is 2,4-Dichloro-5-fluoropyrimidine (2927-71-1) used for?

InChI:InChI=1/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H

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2927-71-1

Product Name：2,4-Dichloro-5-fluorouracil
Molecular Formula：C₄HCl₂FN₂
Purity：99%
Molecular Weight：166.97

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Product Details;

CasNo： 2927-71-1

Molecular Formula： C₄HCl₂FN₂

Appearance： yellow to orange crystalline solid

High Quality 2,4-Dichloro-5-fluorouracil 2927-71-1

Molecular Formula:C4HCl2FN2
Molecular Weight:166.97
Appearance/Colour:yellow to orange crystalline solid
Vapor Pressure:0.148mmHg at 25°C
Melting Point:37-41 °C(lit.)
Refractive Index:1.531
Boiling Point:222.8 °C at 760 mmHg
PKA:-3.96±0.29(Predicted)
Flash Point:88.6 °C
PSA：25.78000
Density:1.605 g/cm³
LogP:1.92250

2927-71-1 Process route

: 51-21-8
5-fluoropyrimidine-2,4-diol

: 2927-71-1
2,4-dichloro-5-fluoropyrimidine

Conditions

Conditions	Yield
With trichlorophosphate; In N,N-dimethyl-aniline; at 100 ℃; for 13h; Inert atmosphere; Large scale;	95%
With pyridine; trichlorophosphate; at 180 ℃; for 2h; under 150.015 - 900.09 Torr; Neat (no solvent);	93%
With dimethyl amine; trichlorophosphate; at 95 - 120 ℃; for 4h;	92%
With N,N-diethylaniline; trichlorophosphate; for 1.66667h; Heating;	89.9%
With dmap; thionyl chloride; bis(trichloromethyl) carbonate; for 10h; Reflux; Green chemistry;	87%
5-fluoropyrimidine-2,4-diol; With hydrogenchloride; triethylamine; trichlorophosphate; at 30 - 40 ℃; for 3h; Heating / reflux; With phosphorus pentachloride; at 50 - 60 ℃; for 2h;

: 4330-22-7
5-fluoro-2,4-dimethoxypyrimidine

: 2927-71-1
2,4-dichloro-5-fluoropyrimidine

Conditions

Conditions	Yield
5-fluoro-2,4-dimethoxypyrimidine; With thionyl chloride; In chloroform; at 0 ℃; for 0.5h; UV-irradiation; With chlorine; In chloroform; at 20 ℃; for 12h; Solvent; Wavelength; UV-irradiation;	98%