367-12-4
- Product Name：2-Fluorophenol
- Molecular Formula：C6H5FO
- Purity：99%
- Molecular Weight：112.104
Product Details;
CasNo： 367-12-4
Molecular Formula： C6H5FO
Appearance： clear colourless to yellow liquid
Export Chinese Factory Supply 2-Fluorophenol 367-12-4 Low Price
- Molecular Formula:C6H5FO
- Molecular Weight:112.104
- Appearance/Colour:clear colourless to yellow liquid
- Vapor Pressure:2.86mmHg at 25°C
- Melting Point:16.1 °C(lit.)
- Refractive Index:1.5140
- Boiling Point:151.5 °C at 760 mmHg
- PKA:8.73(at 25℃)
- Flash Point:46.7 °C
- PSA：20.23000
- Density:1.217 g/cm3
- LogP:1.53130
2-Fluorophenol(Cas 367-12-4) Usage
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Chemical Properties |
Clear colourless to yellow liquid |
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Synthesis Reference(s) |
Tetrahedron, 52, p. 23, 1996 DOI: 10.1016/0040-4020(95)00867-8Journal of the American Chemical Society, 103, p. 1964, 1981 DOI: 10.1021/ja00398a015 |
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General Description |
Liquid or crystalline solid melting at 14-16°C. Corrosive. Density 1.246 g / cm3. |
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Air & Water Reactions |
Highly flammable. |
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Reactivity Profile |
2-Fluorophenol reacts as a weak organic acid. May be incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction with bases. Such heating may initiate polymerization of the organic compound. Sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Nitrated very rapidly, even by dilute nitric acid. |
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Health Hazard |
ACUTE/CHRONIC HAZARDS: Toxic and irritant. |
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Purification Methods |
Pass o-fluorophenol at least twice through a gas chromatographic column for small quantities; otherwise fractionally distil it under reduced pressure. [Beilstein 6 I 97, 6 IV 770.] |
InChI:InChI=1/C6H5FO/c7-5-3-1-2-4-6(5)8/h1-4,8H
367-12-4 Relevant articles
AROMATIC FLUORINE CHEMISTRY. PART 3. PREPARATION OF FLUOROPHENOLS VIA HYDROLYSIS OF CHLOROFLUOROBENZENES
Pews, R. G.,Gall, J. A.
, p. 377 - 380 (1990)
The 1,2-, 1,3-, and 1,4-fluorophenols ha...
Preparation method of 2-fluorophenol
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Paragraph 0003; 0030-0058, (2021/01/25)
The invention relates to the field of fl...
Photo-induced thiolate catalytic activation of inert Caryl-hetero bonds for radical borylation
K?nig, Burkhard,Wang, Hua,Wang, Shun
supporting information, p. 1653 - 1665 (2021/06/17)
Substantial effort is currently being de...
Method for preparing O-fluorophenol by one-pot method
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Paragraph 0023-0025, (2021/04/14)
The invention discloses a method for pre...
Synthesis method of fluorine-containing phenol structure compound
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Paragraph 0025-0026, (2021/03/13)
The invention discloses a synthesis meth...
367-12-4 Process route
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- 108-95-2,27073-41-2
phenol
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- 367-12-4
2-fluorophenol
| Conditions | Yield |
|---|---|
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With acetic acid; Selectfluor; eosin y; In water; at 20 ℃; for 6h; Irradiation; Green chemistry;
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77% |
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Multi-step reaction with 3 steps
1.1: copper(l) iodide; 2-Picolinic acid; potassium phosphate / dimethyl sulfoxide / 24 h / 80 °C / Inert atmosphere
2.1: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide / ethyl acetate / 5 h / 80 °C
3.1: methyl trifluoromethanesulfonate / toluene / 2 h / 100 °C / Inert atmosphere
3.2: 1 h / Reflux; Inert atmosphere
With 2-Picolinic acid; potassium phosphate; copper(l) iodide; N-fluorobis(benzenesulfon)imide; methyl trifluoromethanesulfonate; bis(dibenzylideneacetone)-palladium(0); In dimethyl sulfoxide; ethyl acetate; toluene;
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|
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In 1,2-dichloro-ethane; for 1.5h; Reflux;
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45 %Spectr. |
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- 348-54-9
2-Fluoroaniline
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- 367-12-4
2-fluorophenol
| Conditions | Yield |
|---|---|
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2-Fluoroaniline; With sodium nitrite; In water; hydrogen bromide; at 0 - 10 ℃; for 1.66667h; liquid HBr;
With copper(II) sulfate; In water; hydrogen bromide; toluene; at 60 ℃; Solvent; Reagent/catalyst; Temperature; liquid HBr;
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92.7% |
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2-Fluoroaniline; With nitrosylsulfuric acid; sulfuric acid; In dichloromethane; at 20 ℃; Large scale;
With copper(ll) sulfate pentahydrate; water; In dichloromethane; at 130 ℃; Large scale;
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367-12-4 Upstream products
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321-28-8
1-fluoro-2-methoxybenzene
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451-80-9
1-ethoxy-2-fluoro-benzene
-
108-24-7
acetic anhydride
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95-55-6
2-amino-phenol
367-12-4 Downstream products
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349-21-3
1-(2-fluoro-phenoxy)-4-methoxy-benzene
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2263-18-5
(2-fluoro-phenyl)-octyl ether
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394-50-3
3-fluorosalicylaldehyde
-
405-05-0
3-fluoro-4-hydroxybenzaldehyde
Relevant Products
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1,2,3-Trifluoro-4-nitrobenzeneCAS：771-69-7
-
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2,4-Dichloro-5-fluoroacetophenoneCAS：704-10-9
