881677-11-8
- Product Name：Vonoprazan N -1
- Molecular Formula：C16H11FN2O3S
- Purity：99%
- Molecular Weight：330.339
Product Details;
CasNo： 881677-11-8
Molecular Formula： C16H11FN2O3S
Chinese Manufacturer Supply Vonoprazan N -1 881677-11-8 Export with Safe Delivery
- Molecular Formula:C16H11FN2O3S
- Molecular Weight:330.339
- Boiling Point:563.7±60.0 °C(Predicted)
- PKA:-0.34±0.11(Predicted)
- PSA：77.41000
- Density:1.37±0.1 g/cm3(Predicted)
- LogP:3.81950
881677-11-8 Relevant articles
Identification, characterization, synthesis of major metabolites biotransformed from vonoprazan fumarate
Hu, Ji'an,Kou, Jingping,Li, Jianbing,Li, Yanhua,Lin, Biyue,Wang, Zhongqing,Wu, Shuming,Xiao, Qingbo,Xin, Libo,Zhou, Xinglin,Zhu, Zhu
, (2022/02/10)
A first synthetic research concerning fo...
Preparation method of tenosynol fumarate
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Paragraph 0024-0032, (2021/11/19)
The invention discloses a preparation me...
Preparation method of high-purity vonoprazan fumarate
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Paragraph 0010; 0011, (2021/05/26)
The invention discloses a preparation me...
Preparation method of vonoprazan intermediate
-
, (2021/02/10)
The invention provides a preparation met...
881677-11-8 Process route
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- 16133-25-8
Pyridine-3-sulfonyl chloride
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- 881674-56-2
5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde
-
- 881677-11-8
5‐(2-fluorophenyl)‐1‐(pyridine-3-sulfonyl)-1H-pyrrole-3-carbaldehyde
| Conditions | Yield |
|---|---|
|
With triethylamine; In dichloromethane; at 0 - 20 ℃; for 6h;
|
93.8% |
|
With dmap; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 - 50 ℃; for 2h;
|
90.6% |
|
With dmap; triethylamine; In acetonitrile; at 45 ℃; for 1.5h;
|
88.7% |
|
With potassium tert-butylate; In dichloromethane; at 0 ℃; for 2h; Solvent; Reagent/catalyst; Temperature;
|
88% |
|
With dmap; N,N-diethyl-N-isopropylamine; In acetonitrile; at 15 - 50 ℃; for 3h; Large scale;
|
87.9% |
|
With dmap; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 40 - 50 ℃; for 1h;
|
87% |
|
With N-ethyl-N,N-diisopropylamine; dmap; In acetonitrile; at 40 - 50 ℃; for 1.5h;
|
86.7% |
|
With dmap; triethylamine; In dichloromethane; for 2h;
|
86.6% |
|
With dmap; triethylamine; In acetonitrile; at 50 ℃; Large scale;
|
86% |
|
With triethylamine; In acetonitrile; at 20 - 80 ℃; for 3h;
|
85.4% |
|
5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;
Pyridine-3-sulfonyl chloride; With 15-crown-5; In tetrahydrofuran; at 0 - 20 ℃;
|
82% |
|
With dmap; triethylamine; In dichloromethane; at 10 - 35 ℃; for 3h;
|
78.39% |
|
With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 1.08h;
|
68% |
|
With dmap; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 40 - 50 ℃; for 2h;
|
15.5 g |
|
With triethylamine; In acetonitrile; at 45 ℃; for 1.5h;
|
15 g |
|
With dmap; sodium carbonate; In acetonitrile; at 60 ℃; for 5h;
|
0.83 mol |
|
5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde; With potassium hydroxide; In acetonitrile; at 15 ℃; for 1.5h; Inert atmosphere;
Pyridine-3-sulfonyl chloride; In acetonitrile; at 30 ℃; for 1h; Temperature;
|
294.5 g |
|
With hydrogenchloride; dmap; triethylamine; In water; acetonitrile; at 0 - 45 ℃; for 1.5h; pH=4-5;
|
-
- 881674-56-2
5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde
-
- 42899-76-3
pyridine-3-sulfonyl chloride hydrochloride
-
- 881677-11-8
5‐(2-fluorophenyl)‐1‐(pyridine-3-sulfonyl)-1H-pyrrole-3-carbaldehyde
| Conditions | Yield |
|---|---|
|
5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;
With 15-crown-5; In tetrahydrofuran; for 0.5h;
pyridine-3-sulfonyl chloride hydrochloride; In tetrahydrofuran; for 3h;
|
82% |
|
5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde; With sodium hydride; In tetrahydrofuran; mineral oil; at 10 - 35 ℃; for 0.5h;
With 15-crown-5; In tetrahydrofuran; mineral oil; for 0.5h;
pyridine-3-sulfonyl chloride hydrochloride; In tetrahydrofuran; mineral oil; for 3h;
|
82% |
|
5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde; pyridine-3-sulfonyl chloride hydrochloride; With dmap; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 45 ℃; for 5h;
With hydrogenchloride; In water; acetonitrile; at 10 - 20 ℃; for 1.5h; pH=5;
|
78% |
|
In tetrahydrofuran;
|
881677-11-8 Upstream products
-
42899-76-3
pyridine-3-sulfonyl chloride hydrochloride
-
881674-56-2
5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde
-
1240948-72-4
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
-
312307-38-3
2-[2-(2-fluorophenyl)-2-oxoethyl]propanedinitrile
881677-11-8 Downstream products
-
881681-00-1
1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-yl)-N-methylmethanamine
-
928324-99-6
2-bromo-5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
-
2098974-13-9
1-[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-yl]-N-methylmethylamine fumaric acid salt
-
2098974-13-9
(x)C4H4O4*C17H16FN3O2S
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