355806-00-7
- Product Name：tert-Butyl rosuvastatin
- Molecular Formula：C26H36FN3O6S
- Purity：99%
- Molecular Weight：537.653
Product Details;
CasNo： 355806-00-7
Molecular Formula： C26H36FN3O6S
Appearance： white to off-white crystal powder
Hot Sale Buy Quality tert-Butyl rosuvastatin 355806-00-7 Efficient Transportation
- Molecular Formula:C26H36FN3O6S
- Molecular Weight:537.653
- Appearance/Colour:white to off-white crystal powder
- Vapor Pressure:0mmHg at 25°C
- Refractive Index:1.564
- Boiling Point:704.158 °C at 760 mmHg
- PKA:13.38±0.20(Predicted)
- Flash Point:379.661 °C
- PSA：138.30000
- Density:1.26 g/cm3
- LogP:4.73960
tert-Butyl rosuvastatin(Cas 355806-00-7) Usage
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Uses |
Rosuvastatin tert-Butyl Ester, is a metabolite of Rosuvastatin (R700500) a selective, competitive HMG-CoA reductase inhibitor. |
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Consumer Uses |
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment. |
InChI:InChI=1/C26H36FN3O6S/c1-16(2)23-21(13-12-19(31)14-20(32)15-22(33)36-26(3,4)5)24(17-8-10-18(27)11-9-17)29-25(28-23)30(6)37(7,34)35/h8-13,16,19-20,31-32H,14-15H2,1-7H3/b13-12+/t19-,20-/m1/s1
355806-00-7 Relevant articles
PROCESS FOR MANUFACTURE OF ROSUVASTATIN CALCIUM AMORPHOUS
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Page/Page column 7; 8, (2019/01/22)
Disclosed here is a process for the prep...
Purification method of rosuvastatin calcium key intermediate
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Paragraph 0053-0055, (2019/05/08)
The invention provides a purification me...
INTERMEDIATE COMPOUND FOR PREPARING ROSUVASTATIN CALCIUM AND METHOD FOR PREPARING ROSUVASTATIN CALCIUM THEREFROM
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, (2017/02/24)
Provided are an intermediate compound fo...
Synthesis method of chiral isomer impurities of rosuvastatin calcium
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Paragraph 0034-0036; 0042, (2017/12/27)
The invention relates to a synthesis met...
355806-00-7 Process route
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![(+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoic acid tert-butyl ester](/upload/2023/8/1a215925-7783-4c01-b302-4b4f683045b3.png)
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(+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoic acid tert-butyl ester
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- 355806-00-7
rosuvastatin tert-butyl ester
| Conditions | Yield |
|---|---|
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(+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoic acid tert-butyl ester; With triethyl borane; In tetrahydrofuran; methanol; at -78 ℃; for 0.25h; Inert atmosphere;
With sodium tetrahydroborate; In tetrahydrofuran; methanol; at -78 ℃; for 0.5h; Inert atmosphere;
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90.6% |
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(+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoic acid tert-butyl ester; With diethyl methoxy borane; In tetrahydrofuran; methanol; at -78 ℃; for 0.5h;
With sodium tetrahydroborate; In tetrahydrofuran; methanol; for 3h;
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86% |
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With sodium hydroxide; water; In ethanol; at 20 ℃; for 2h;
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With sodium tetrahydroborate; diethyl methoxy borane; In tetrahydrofuran; methanol; at -78 - -75 ℃; for 1.5h;
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10.5 g |
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- 1235588-97-2
tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2-phenyl-1,3-dioxan-4-yl)acetate
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- 355806-00-7
rosuvastatin tert-butyl ester
| Conditions | Yield |
|---|---|
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tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2-phenyl-1,3-dioxan-4-yl)acetate; With water; acetic acid; at 40 - 60 ℃; for 3h;
With sodium hydrogencarbonate; In water; ethyl acetate;
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95% |
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With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 1h;
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95% |
355806-00-7 Upstream products
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289042-12-2
2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester
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910867-13-9
(5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-5-(hydroxy)-3-oxo-(6E)-heptenoic acid tert-butyl ester
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1007871-85-3
tert-butyl-6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
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1235588-97-2
tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2-phenyl-1,3-dioxan-4-yl)acetate
355806-00-7 Downstream products
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287714-41-4
rosuvastatin
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917805-72-2
C4H11N*C22H28FN3O6S
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917805-79-9
rosuvastatin tetramethyl ammonium salt
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862994-56-7
E-7-[2-(N-methyl-N-methanesulfonylamino)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid diisopropylamine salt
Relevant Products
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